Today, Pataigin founder Prof. Robert Ernst presented results of a new assay that determines microbial ID and colistin resistance in one hour, direct from clinical specimens. The assay uses lipid microbiology with the FLAT extraction technique to allow colistin resistance to be rapidly determined without culture.
Polymyxins – polymyxin B and polymyxin E (colistin) are increasingly used worldwide to treat patients with multidrug-resistant (MDR) Gram-negative bacterial infections. However, there currently is no reliable test for colistin resistance, complicating colistin treatment and increasing risks to patients. Prof. Ernst demonstrated that Pataigin’s FLAT technique can be reliably used to identify colistin resistance. The rapid and accurate test presented by Prof. Ernst promises to improve the safety and efficacy of colistin therapy.
The talk was entitled “Rapid Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin Resistance,” and was presented in World Microbe Forum session AAR104. Prof. Ernst is the Dr. Paul and Mrs. Jean Corcoran Professor and Vice-Chair, Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore.
Pataigin is developing lipid microbiology tests for bacterial ID, antimicrobial resistance, and antimicrobial susceptibility.