Pataigin Introduces First Multiplex Lipid Microbiology Kit

VIENNA, Austria, BALTIMORE Maryland, and Seattle, Washington – 13 July 2021: At the 31st European Congress of Clinical Microbiology & Infectious Diseases (ECCMID, www.eccmid.org), Pataigin introduced the BACLIB Rapid Lipid Extraction Kit for microbial identification and colistin resistance detection.

The patented BACLIB Kit is unique in determining bacterial species ID and colistin resistance with a single assay. Superior to competing lipid microbiology kits, BACLIB requires less than a minute of hands-on time per sample, with no centrifugation or complex handling steps.

In contrast to competing kits that only identify a single species, the multiplex BACLIB Kit identifies and determines colistin resistance for all the ESKAPE pathogens. The BACLIB Kit includes access to custom software for ID/resistance determination. Time-to-result is only 30 minutes.

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Pataigin Awarded NIH Grant to Improve Antimicrobial Stewardship

Today, the US NIH awarded Pataigin a research grant to further development of Pataigin’s Rigel antimicrobial susceptibility test.

“We thank the NIH for supporting this research,” said Pataigin CEO Erik Nilsson. “Rigel promises to reduce medical costs while saving lives now lost to infectious disease.”

The grant, entitled Isotopic Labeling Rapid Antimicrobial Susceptibility Testing, furthers development of a rapid and sensitive Rigel AST test using lipid microbiology technology. Rigel can determine appropriate antibiotic therapy in six hours, compared to days for conventional tests.

“Rigel is based on my lab’s longstanding research into lipid microbiology,” said Prof. Robert Ernst, the Dr. Paul and Mrs. Jean Corcoran Professor and Chair, Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore. “In this research, we extend lipid microbiology beyond microbial ID to antimicrobial susceptibility testing.” Prof. Ernst is a collaborator on the grant.

Bacteremia and sepsis remain major health problems with high mortality. Progression is often rapid, so that a single hour saved in diagnosis time can significantly reduce septicemia death rates. Faster tests are therefore needed to save lives. By significantly accelerating test results, Rigel assay offers the potential of improved clinical outcomes at lower cost to hospitals.

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Pataigin Founder Ernst Presents Rapid Colistin Assay at World Microbe Forum

Today, Pataigin founder Prof. Robert Ernst presented results of a new assay that determines microbial ID and colistin resistance in one hour, direct from clinical specimens. The assay uses lipid microbiology with the FLAT extraction technique to allow colistin resistance to be rapidly determined without culture.

Polymyxins – polymyxin B and polymyxin E (colistin) are increasingly used worldwide to treat patients with multidrug-resistant (MDR) Gram-negative bacterial infections. However, there currently is no reliable test for colistin resistance, complicating colistin treatment and increasing risks to patients. Prof. Ernst demonstrated that Pataigin’s FLAT technique can be reliably used to identify colistin resistance. The rapid and accurate test presented by Prof. Ernst promises to improve the safety and efficacy of colistin therapy.

The talk was entitled “Rapid Lipid-Based MALDI-TOF Assay for the Rapid Detection of Colistin Resistance,” and was presented in World Microbe Forum session AAR104. Prof. Ernst is the Dr. Paul and Mrs. Jean Corcoran Professor and Chair, Department of Microbial Pathogenesis, School of Dentistry, University of Maryland, Baltimore.

Pataigin is developing lipid microbiology tests for bacterial ID, antimicrobial resistance, and antimicrobial susceptibility.

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Published results: BACLIB Method IDs Pathogens and Colistin Resistance in One Hour

Scientific Reports today published a paper describing the FLAT rapid extraction method that allows identification of bacteria and fungi in one hour. Determination of colistin resistance in Gram-negative bacteria is also demonstrated. The paper was authored by Pataigin personnel in collaboration with the labs of BACLIB inventors Prof. Robert Ernst and Prof. David Goodlett. … Continue readingPublished results: BACLIB Method IDs Pathogens and Colistin Resistance in One Hour