Unique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis

Ernst RK, Moskowitz SM, Emerson JC, et al. J Infect Dis. 2007 Oct

Three structural features of lipid A (addition of palmitate [C16 fatty acid], addition of aminoarabinose [positively charged amino sugar residue], and retention of 3-hydroxydecanoate [3-OH C10 fatty acid]) were determined for Pseudomonas aeruginosa isolates from patientswith cystic fibrosis (CF; n = 86), from the environment (n = 13), and from patients with other conditions (n = 14). Among P. aeruginosa CF isolates, 100% had lipid A with palmitate, 24.6% with aminoarabinose, and 33.3% retained 3-hydroxydecanoate. None of the isolates from the environment or from patients with other conditions displayed these modifications. These results indicate that unique lipid A modifications occur in clinical CF isolates. … Continue readingUnique lipid A modifications in Pseudomonas aeruginosa isolated from the airways of patients with cystic fibrosis